| 中医药靶向肿瘤干细胞的研究进展与展望 |
| Advances and Prospects of Traditional Chinese Medicine in Targeting Cancer Stem Cells |
| DOI： |
| 中文关键词: 肿瘤干细胞 中医药 信号通路 中药单体 中药复方 |
| 英文关键词: Scancer stem cells traditional Chinese medicine signaling pathways monomeric compounds from Chinese medicine Chinese herbal formulas |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 肿瘤干细胞(cancer stem cells, CSCs)是导致肿瘤耐药、复发与转移的关键细胞亚群,传统治疗难以根除。中医药基于“扶正祛邪”整体观念,在调节肿瘤微环境、改善机体免疫方面具有独特优势。本文系统综述中医药靶向CSCs的研究进展。研究表明,中药活性成分(如人参皂苷、姜黄素、小檗碱、白藜芦醇、吴茱萸碱等)及复方(如四君子汤、解毒消癥饮、鳖甲煎丸等)可通过多靶点干预Wnt/β-catenin、Notch、Hedgehog、STAT3等信号通路,抑制CSCs自我更新、干性标志物表达及耐药性,协同增强常规治疗疗效。中医理论将CSCs归属于“痰浊”“伏毒”“瘀血”等实邪,病机强调脾虚肾亏所致的正虚邪恋,治法注重化痰解毒祛瘀与健脾补肾相结合。未来需整合单细胞技术、纳米递送系统及高质量临床试验,深入解析中医药调控CSCs的机制,为中西医结合肿瘤治疗提供新策略。 |
| 英文摘要: |
| Cancer stem cells (CSCs) are a crucial subpopulation of cells responsible for tumor drug resistance, recurrence, and metastasis, and they are difficult to eradicate with conventional therapies. Traditional Chinese medicine (TCM), grounded in the holistic concept of “strengthening vital qi and eliminating pathogens” (Fuzheng Quxie), offers unique advantages in modulating the tumor microenvironment and enhancing systemic immunity. This article systematically reviews the research progress of TCM in targeting CSCs. Studies have demonstrated that active TCM ingredients (e.g., ginsenosides, curcumin, berberine, resveratrol, and evodiamine) and compound formulas (e.g., Sijunzi Decoction, Jiedu Xiaozheng Decoction, and Biejiajian Pill) can intervene through multiple targets in signaling pathways such as Wnt/β-catenin, Notch, Hedgehog, and STAT3, thereby inhibiting CSCs self-renewal, stemness marker expression, and drug resistance, and synergistically enhancing the efficacy of conventional treatments. According to TCM theory, CSCs are categorized as excessive pathogenic factors such as “phlegm turbidity,” “latent toxin,” and “blood stasis.” The pathogenesis emphasizes the lingering of pathogens due to deficient healthy qi caused by spleen and kidney deficiency, and the therapeutic principle focuses on the combination of resolving phlegm, removing toxin, and eliminating blood stasis with invigorating the spleen and tonifying the kidney. Future research should integrate single-cell technologies, nano-delivery systems, and high-quality clinical trials to deeply elucidate the mechanisms by which TCM regulates CSCs, thereby providing new strategies for cancer treatment with integrated traditional Chinese and Western medicine. |
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