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| 火针赞刺法联合黄连紫草膏治疗急性带状疱疹的临床研究 |
| Clinical Study on Fire-Needle Pricking Technique Combined with Coptis and Arnebia Paste in Treating Acute Herpes Zoster |
| 投稿时间：2026-07-04 修订日期：2026-07-06 |
| DOI： |
| 中文关键词: 带状疱疹 火针 赞刺法 黄连紫草膏 带状疱疹后神经痛 |
| 英文关键词: Herpes zoster Fire needle Zanci Therapy Coptis and Arnebia ointment Postherpetic neuralgia |
| 基金项目:①国家中医药传承创新中心联合共建项目(2024ZXZX1104) |
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| 中文摘要: |
| 目的?：评价火针赞刺法联合黄连紫草膏治疗急性带状疱疹的临床疗效与安全性。方法：采用随机对照研究设计,本研究初始纳入 83 例患者,经病例脱落与剔除后,最终完成研究并纳入统计分析共 77 例,其中火针组 38 例,西药组 39 例。西药组予口服伐昔洛韦、甲钴胺及加巴喷丁；火针组在此基础上联合皮损区火针赞刺、拔罐及黄连紫草膏外敷,疗程7～10天。比较两组症状积分、心理评分、疗效等级、PHN发生率及安全性。结果：治疗后,火针组症状体征积分(5.31±1.89分)低于西药组(6.60±1.55分)(P＜0.001)；其在HAMA、HAMD及SCL-90评分的改善也更优(P＜0.001)。疗效等级比较显示,火针组总有效率(97.37%)及疗效分布优于西药组(84.62%)(P=0.042)。随访期火针组PHN发生率(7.89%)低于西药组(23.08%)(P=0.032)。两组不良事件均轻微,发生率低。结论?：在西医常规治疗基础上联合火针赞刺与黄连紫草膏,可更有效地缓解急性带状疱疹患者的身心症状,提高疗效,降低PHN风险,且安全性良好。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy and safety of fire-needle pricking combined with Coptis and Arnebia ointment in the treatment of acute herpes zoster. Methods: A randomized controlled study design was adopted. A total of 83 patients were initially enrolled in this study. After case loss and exclusion, 77 patients finally completed the trial and were included for statistical analysis, including 38 cases in the fire-needle group and 39 cases in the western medicine group. Patients in the western medicine group were given oral valacyclovir, mecobalamin and gabapentin. On this basis, the fire-needle group was additionally treated with fire-needle Zanci puncture, cupping therapy and external application of Coptis Chinensis and Arnebia Root ointment on the skin lesions, with a treatment course of 7–10 days. The symptom scores, psychological scale scores, clinical efficacy grade, incidence of postherpetic neuralgia (PHN) and safety indicators were compared between the two groups. Results: After treatment, the symptom and sign score of fire-needle group was (5.31±1.89) points, which was lower than (6.60±1.55) points of western medicine group (P＜0.001). The improvement of HAMA, HAMD and SCL-90 scores in fire-needle group was better than that in western medicine group (P＜0.001). The total clinical effective rate of fire-needle group was 97.37%, which was higher than 84.62% of western medicine group (P=0.042). After 1-month follow-up, the incidence of postherpetic neuralgia was 7.89% in fire-needle group, lower than 23.08% in western medicine group (P=0.032). Adverse reactions of the two groups were mild and could be relieved spontaneously, with good safety. Conclusion: Combined application of fire-needle pricking and Coptis and Arnebia ointment on the basis of conventional western medicine can obviously relieve clinical symptoms and negative emotions of patients with acute herpes zoster, improve curative effect and reduce the risk of postherpetic neuralgia, which is safe and worthy of clinical promotion. |
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