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| 骨碎补总黄酮通过调控骨代谢微环境防治骨质疏松症的研究进展 |
| Advances in Total Flavonoids of Drynaria for the Prevention and Treatment of Osteoporosis Through Modulation of the Bone Metabolic MicroenvironmentYU Zijian, HUANG Qing, CHEN Longju? |
| 投稿时间：2026-08-03 修订日期：2026-08-03 |
| DOI： |
| 中文关键词: 骨碎补总黄酮 骨质疏松症 骨代谢微环境 骨免疫 氧化应激 |
| 英文关键词: total flavonoids from Drynariae Rhizoma osteoporosis bone metabolic microenvironment osteoimmunology oxidative stress |
| 基金项目:湖北省自然科学创新发展联合基金(项目号2026AFC0213)湖北民族大学2026年研究生科研创新项目(No.MYK2026057)第一 |
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| 中文摘要: |
| 骨质疏松症(osteoporosis,OP)的病理基础并非单纯的成骨不足或骨吸收增强,而是内分泌、免疫、BMSCs成骨—成脂分化失衡等多维因素共同作用,导致骨代谢微环境中多类细胞交流失衡。骨碎补总黄酮是骨碎补发挥骨保护作用的重要活性部位,其代表性成分主要包括柚皮苷、柚皮素等。现有研究提示,骨碎补总黄酮及其代表性成分可通过调节雌激素受体相关信号、纠正BMSCs成骨—成脂分化偏移等途径,改善OP骨代谢微环境。既往研究多从分子通路角度阐述骨碎补总黄酮防治骨质疏松症的作用机制,本文以骨代谢微环境为切入点进行综述,以期为其抗骨质疏松作用研究及临床应用提供参考。 |
| 英文摘要: |
| The pathological basis of osteoporosis (OP) involves not merely impaired bone formation or excessive bone resorption, but also the combined effects of multiple factors, including endocrine dysfunction, immune dysregulation, and an imbalance between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), ultimately leading to disrupted intercellular communication within the bone metabolic microenvironment. Total flavonoids from Drynariae Rhizoma constitute an important bioactive fraction responsible for its bone-protective effects, with naringin and naringenin being representative constituents. Current evidence suggests that total flavonoids from Drynariae Rhizoma and their representative constituents may improve the bone metabolic microenvironment in OP by regulating estrogen receptor-related signaling and correcting the shift of BMSCs from osteogenic toward adipogenic differentiation. Previous studies have mainly discussed their anti-osteoporotic mechanisms from the perspective of molecular signaling pathways. Therefore, this review summarizes the relevant evidence from the perspective of the bone metabolic microenvironment, aiming to provide a reference for further investigation and clinical application of total flavonoids from Drynariae Rhizoma in the prevention and treatment of OP. |
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