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| 黄连丸治疗糖尿病肾病的中医理论基础、药理证据与潜在机制 |
| Theoretical Basis in Traditional Chinese Medicine, Pharmacological Evidence, and Potential Mechanisms of Huanglian Pill for Diabetic Kidney Disease |
| 投稿时间：2026-09-21 修订日期：2026-09-21 |
| DOI： |
| 中文关键词: 黄连丸 糖尿病肾病 中医药 药理作用 作用机制 |
| 英文关键词: huanglian pill diabetic kidney disease traditional Chinese medicine pharmacological effects mechanisms of action |
| 基金项目:同济医院基金 |
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| 中文摘要: |
| 糖尿病肾病(diabetic kidney disease,DKD)是糖尿病常见的微血管并发症,其病理机制复杂,现有治疗仍难以完全阻止肾功能持续下降。中医学将其归属于消渴病肾病范畴,病机以本虚标实、虚实夹杂为特点。黄连丸由黄连、生地黄组成,清热与养阴并用,与DKD阴津亏损、热邪内蕴及湿瘀交阻的病机相契合。现代研究表明,黄连丸及其相关成分可能通过改善糖脂及肾脏能量代谢、减轻炎症反应与氧化应激、保护肾小球滤过屏障,以及抑制肾小管损伤和肾纤维化发挥肾脏保护作用。本文从中医理论基础、现代药理作用及潜在机制等方面进行综述,旨在为黄连丸治疗DKD提供依据。 |
| 英文摘要: |
| Diabetic kidney disease (DKD) is a common microvascular complication of diabetes. Its pathogenesis is complex, and current therapies cannot completely halt the progressive decline in kidney function. In traditional Chinese medicine (TCM), DKD falls within the category of Xiaoke kidney disease and is characterized by root deficiency and branch excess, with deficiency and excess occurring simultaneously. Huanglian Pill, composed of Coptidis Rhizoma and Rehmanniae Radix, combines heat-clearing with yin-nourishing effects and corresponds to the pathogenesis of yin-fluid depletion, internal accumulation of heat, and intermingled dampness and blood stasis in DKD. Modern studies suggest that Huanglian Pill and its related constituents may exert renoprotective effects by regulating glucose and lipid metabolism and renal energy metabolism, attenuating inflammation and oxidative stress, preserving the glomerular filtration barrier, and inhibiting renal tubular injury and fibrosis. This article reviews the TCM theoretical basis, modern pharmacological effects, and potential mechanisms of Huanglian Pill, aiming to provide a scientific basis for its use in the treatment of DKD. |
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