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| 红景天苷在抗器官纤维化中的研究进展 |
| Research progress of salidroside in anti organ fibrosis |
| 投稿时间：2026-10-08 修订日期：2026-10-19 |
| DOI： |
| 中文关键词: 器官纤维化 红景天苷 多途径 药理作用 研究进展 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 器官纤维化是多种慢性疾病的终末特征,是导致器官功能衰竭的主要原因,在世界范围内有着较高的致死、致残率,造成了严重的健康和经济负担。但是目前临床药物通常功效有限,且毒副作用明显。红景天苷作为红景天的主要有效成分,已发现具有广泛的药理作用。国内外研究表明,红景天苷通过调控多种和纤维化密切相关途径,包括氧化应激、炎症、线粒体功能、细胞凋亡、自噬、细胞外基质(ECM)蓄积及上皮间质转化(EMT)等抑制纤维化进程。通过对近年来红景天苷治疗纤维化疾病的系统归纳,以期为纤维化疾病的临床治疗提供新的思路。 |
| 英文摘要: |
| Organ fibrosis is the terminal characteristic of a variety of chronic diseases and the main cause of organ failure. It has a high mortality and disability rate worldwide, causing serious health and economic burden. However, clinical drugs usually have limited efficacy and obvious side effects. Salidroside as the main active component of salidroside has been found to have a wide range of pharmacological effects. Domestic and foreign studies have shown that salidroside inhibits the fibrosis process by regulating a variety of pathways closely related to fibrosis, including oxidative stress, inflammation, mitochondrial function, apoptosis, autophagy, extracellular matrix (ECM) accumulation and epithelial-mesenchymal transition (EMT). To provide new ideas for the clinical treatment of fibrotic diseases by systematically summarizing the treatment of salidroside in recent years. |
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