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| 小蓟饮子加减预防继发性输尿管狭窄的随机对照临床研究 |
| Randomized Controlled Clinical Study of Modified Xiaoji Yinzi in Prevention of Secondary Ureteral Stricture |
| 投稿时间：2026-10-15 修订日期：2026-10-15 |
| DOI： |
| 中文关键词: 小蓟饮子加减 输尿管镜碎石术 继发性输尿管狭窄 石淋 |
| 英文关键词: modified Xiaoji Yinzi ureteroscopic lithotripsy secondary ureteral stricture stone stranguria |
| 基金项目:福建省自然科学基金资助项目(2023J011852) |
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| 中文摘要: |
| 目的:探讨小蓟饮子加减对输尿管镜钬激光碎石术(URSL)术后继发性输尿管狭窄的预防效果及安全性。方法:选取 2023?2026 年福建中医药大学附属漳州中医院泌尿外科收治的 62 例输尿管中上段嵌顿结石患者,采用随机数字表法分为治疗组 32 例与对照组 30 例。治疗组在URSL术后第 1 天开始口服小蓟饮子加减方,连续 4 周,对照组术后给予安慰剂对照。术后 12 周评估输尿管狭窄发生情况,同时观察术后肉眼血尿持续时间、血清肌酐及不良事件发生情况。结果:术后 12 周,治疗组继发性输尿管狭窄发生率 6.2%(2/32),低于对照组 26.7%(8/30)(P=0.040)；治疗组肾盂前后径小于对照组(P=0.037)；治疗组术后肉眼血尿持续时间显著短于对照组(P＜0.001)；两组术后血肌酐水平比较差异无统计学意义(P=0.980)。两组不良反应发生率差异无统计学意义(P＞0.05),未见严重不良反应。结论:小蓟饮子加减能够降低输尿管镜钬激光碎石术后继发性输尿管狭窄发生率,缩短术后肉眼血尿时间,安全性良好,值得临床进一步研究。 |
| 英文摘要: |
| Objective:To investigate the preventive effect and safety of modified Xiaoji Yinzi on secondary ureteral strictures after ureteroscopic holmium laser lithotripsy(URSL). Methods: A total of 62 patients with incarcerated upper?middle ureteral calculi treated in the Department of Urology, Zhangzhou Hospital of traditional Chinese medicine, affiliated to Fujian University of traditional Chinese medicine between 2023 to 2026 were enrolled and divided into treatment group (n=32) and control group (n=30) by random number table method.The treatment group took? modified Xiaoji Yinzi on the first day after URSL operation for 4 weeks, and the control group was given placebo after operation. The incidence of ureteral stenosis was evaluated 12 weeks after operation, the duration of postoperative gross hematuria, serum creatinine and adverse events were also observed. Results: At 12?week follow?up, the incidence of secondary ureteral strictures in the treatment group was 6.2% (2/32), which was significantly lower than 26.7% (8/30) in the control group (P=0.040). The anterior?posterior diameter (APD) of renal pelvis in the treatment group was smaller than that in the control group (P=0.037). The duration of postoperative gross hematuria in the treatment group was markedly shorter (P＜0.001). There was no significant difference in postoperative serum creatinine between two groups (P=0.980). No significant difference was found in the incidence of adverse events between groups (P＞0.05), and no serious adverse reactions occurred. Conclusion: Modified Xiaoji Yinzi can reduce the incidence of secondary ureteral strictures after URSL and shorten the duration of postoperative gross hematuria with favorable safety profile, which deserves further clinical investigation. |
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