| Discovery of Internal and External TCM Treatments for Myopia Based on the Ancient and Modern Medical Case Cloud Platform: An Analysis of Drug Use and Acupoint Selection Patterns in 161 CasesJinyan Wang1,Ziyun Zeng2, Qingyuan Ji2,Feiyang Long1,Yifei Ye2, Sirui Chen3,Fuyue Lu3,Qinqin Zhou2,Bingxue Liang1* |
| DOI： |
| En KeyWords: Myopia Capable of seeing near but fearful of distant vision Traditional Chinese Medicine (TCM) Ancient and Modern Medical Cases Cloud Platform Acupoint combination |
| Fund Project:重庆中医药学院“三栖名师”能力提升项目SQMS2024QNXM-18；重庆市教育委员会科学技术研究项目KJQN202215106, KJQN202315121；重庆市2025年大学生创新训练计划项目S202514830003 |
| Author:Jinyan Wang |
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| En Abstract: |
| Objective Through data mining techniques, the core acupoint compatibility, patterns of Chinese materia medica properties, and the "local-distal" acupoint selection paradigm in Traditional Chinese Medicine (TCM) internal and external therapeutics for myopia, thereby providing an evidence-based foundation for clinical protocol optimization.Methods Effective medical cases on internal and external TCM treatment of myopia were collected and organized. The data were cleaned and standardized using the Ancient and Modern Medical Case Cloud Platform. Frequency analysis and association rule mining methods were applied to deeply analyze the meridian tropism, five flavors, commonly used herbs, core acupoint combinations, and compatibility patterns involved in myopia treatment.Results Based on data mining methodologies, this study analyzed 161 traditional Chinese medical prescriptions and clinical cases, encompassing 173 herbal components with a cumulative frequency of 710 occurrences, and 14 acupoints with a cumulative frequency of 569 occurrences, thereby elucidating the underlying principles of herbal formulation and acupoint selection in the external treatment of myopia.Herbal analysis showed that the medicines used to treat myopia primarily belonged to the liver meridian (41.63%), spleen meridian (27.85%), and lung meridian (26.3%). The predominant flavors were sweet (44.3%), bitter (28.27%), and pungent (23.77%). Commonly used core herbs included Chrysanthemum, Angelica sinensis, Astragalus membranaceus, Codonopsis pilosula, and Lycium barbarum. Acupoint analysis identified periocular points such as Cuanzhu, Taiyang, Yuyao, Jingming, and Sibai as core treatment sites. Association rule mining revealed high-frequency combinations like “Cuanzhu–Taiyang” (support 0.25), “Cuanzhu–Yuyao” (support 0.24), and “Sizhukong–Cuanzhu” (support 0.24). Additionally, distal acupoint combinations such as “Guangming–Fengchi ” (lift 2.88) were identified, reflecting a treatment philosophy that integrates local syndrome differentiation with holistic regulation. Conclusion The treatment emphasizes liver soothing and eye brightening, spleen strengthening, and qi tonification. Acupoint selection prioritizes periocular local points combined with distal meridian points for overall adjustment. |
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