| Objective To investigate the clinical efficacy and safety of Pei "s Lanzhou Decoction combined with recombinant human thrombopoietin (rhTPO) in the treatment of chemotherapy-induced thrombocytopenia (CIT) with yin deficiency and fire hyperactivity syndrome.Methods A total of 100 CIT patients with yin deficiency and fire excess syndrome admitted in our hospital were selected as the research objects.They were divided into control group and observation group by random number table method, with 50 cases in each group.The control group was treated with rhTPO alone, and the observation group was treated with Pei"s Lanzhou prescription on the basis of the control group. The course of treatment in both groups was 14d. The clinical efficacy and adverse reactions, platelet count (PLT), platelet recovery related indicators and TCM syndrome scores before and after treatment were compared between the two groups.Results After treatment, the total clinical effective rate of the observation group was 98.00%, which was significantly higher than 86.00% of the control group (P<0.05). After 7 d, 10 d and 14 d of treatment, the PLT levels of the two groups were significantly higher than those before treatment ( P < 0.05 ), and the PLT level of the observation group was significantly higher than that of the control group (P<0.05). After treatment, the time of platelet recovery to ≥75×109/L and ≥ 100×109/L in the observation group was significantly shorter than that in the control group (P<0.05), and the duration of platelet ≤50×109/L was significantly shorter than that in the control group (P<0.05). After treatment, the score of yin deficiency and fire excess syndrome in the observation group was significantly lower than that in the control group? (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P> 0.05).Conclusion Pei"s Lanzhou Prescription combined with recombinant human thrombopoietin in the treatment of CIT with Yin deficiency and fire hyperactivity syndrome can significantly increase the platelet count, accelerate the recovery of platelets, and effectively improve the Yin deficiency and fire hyperactivity syndrome. The clinical efficacy is definite and the safety is good. |